Deriving time-concordant event cascades from gene expression data: A case study for Drug-Induced Liver Injury (DILI)
Fig 3
Distribution and relation of histopathological findings across time series.
A) Histopathology labels are defined for each histopathological finding at 3 different toxscore cut-offs, namely “null” (toxscore>0), “low” (toxscore>0.67) and “high” (toxscore>1.34). For each label, the number of occurrences in the 40 adverse time series and the fraction of adverse time series among all occurrences of the given histopathology label are shown. Histopathological findings, out of which at least 50% and at least 5 of the occurrences were found in adverse conditions timeseries were considered adverse B) Number of conditions with histopathological findings at different timepoints, as well as the frequency of the respective first activations C) Time of first activation across timeseries labelled as adverse or non-adverse. Each time series is annotated with the dose level in repeat-dose studies, as well as with whether or not the time series was considered adverse by Sutherland et al. [15].