Experimental guidance for discovering genetic networks through hypothesis reduction on time series
Fig 7
Local versus global node participation scores for the yeast cell cycle network.
Mean ± standard deviation node participation scores for the four scenarios S+A+, S+A−, S−A+, and S−A−. Each scenario was run through the edge and network finding steps five times. The mean (blue dots) and standard deviation (blue bars) of the local node participation scores across the five runs is plotted against the mean and standard deviation of the global node participation scores. The node participation score for each simulation is computed only over the edges in the intersection of the top-ranked LEM edges of all five simulations. This excludes edges that do not have sufficiently high local edge ranks in all five simulations. Nodes located above the red diagonal line indicate an improved global node participation score versus their local node participation score.