Design and execution of a verification, validation, and uncertainty quantification plan for a numerical model of left ventricular flow after LVAD implantation
Fig 1
Leftmost side: Schematic of the experiment setup.
LA: left atrium, MV: Mitral valve, AV: Aortic valve, Ao: aorta. Flow and pressure sensors are indicated in blue and red respectively. The body lumped system is afterwards characterised with a three element Windkessel model with parameters Rp, Rs and Cp. Center: variables extracted from the benchtop experiment to create the simulation and address the uncertainty quantification (UQ). Rightmost side: Schematic of the simulation, including the lumped models for the boundary conditions. The measured PLA is imposed in the mitral valve. The measured Rp, Rs and Cp are used in a three element Windkessel boundary condition at the Aortic valve output. The H-Q curve retrieved and measured is used as a dynamic boundary condition in the LVAD outflow. The benchtop piston dynamics is used as boundary condition for the deformable LV geometry.