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The catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2)

Fig 2

Overview of modeled MTHFD2 system, with THF and NAD⁺ binding pockets. (a) Homodimer overview (b) THF binding scenario (c) NAD⁺ binding scenario.

doi: https://doi.org/10.1371/journal.pcbi.1010140.g002