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The catalytic mechanism of the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2)

Fig 1

(a) The MTHFD2 reaction scheme. (b) The dehydrogenase (D) activity. Note that the QM region indicates the EVB atoms used for our empirical valence bond simulation of the D activity. R = p-aminobenzoyl-glutamate, R₁ = Ribose-ADP.

doi: https://doi.org/10.1371/journal.pcbi.1010140.g001