Interpreting and de-noising genetically engineered barcodes in a DNA virus
Fig 8
Distributions of the barcode pairwise distances within the plasmid library (panel A, shown in blue) and 5,000 randomly generated 12mers (panel B, shown in yellow).
The figure represents the pairwise Levenshtein distances between centroids in the plasmid library after applying a L3 clustering distance and a 99% reads cutoff. The 5,000 randomly generated 12mers are not clustered, and with no cutoff. Data show that the proportion of possible barcode sequence space covered is similarly sparse in both cases.