Genome-wide cross-cancer analysis illustrates the critical role of bimodal miRNA in patient survival and drug responses to PI3K inhibitors
Fig 4
Patient stratification and survival analysis using bimodal miRNA modules.
(A-H) Hierarchical clustering was performed using bimodal miRNA co-expression modules, and patients were divided into two groups. (I-P) Using the two groups, a Cox proportional hazards regression was fit for each cancer type. The reported hazard ratio (HR) denotes the risk of death in Group 2 (purple) compared to Group 1 (green). The statistical significance (p-value) of each HR was determined using a Wald test.