Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models
Fig 6
Certain coupling conditions restore automaticity to a prevalently dormant SA node tissue.
(A) Effect of Ca2+ blockade in the Fabbri model with published parameters. (B) Distribution of PCaL in the tissue at varying degrees of Ca2+ blockade (cellular heterogeneity factor σ equals 0.1). (C) Comparison of the electrical activity of a cell within the tissue (σ equals 0.1) before and after blockade of Ca2+ by 50%. (D) Dormant cells within the tissue beat at intermediate values of coupling. (E) Quantification of the average tissue CL, APA and APD at varying degrees of Ca2+ blockade.