Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models
Fig 3
Cells forming the tissue have been divided into different categories, depending on whether they exhibited action potentials, or not, under both coupled and uncoupled conditions. Alterations in intercellular coupling can cause an individual cell to switch categories, for instance from dormant at one value of coupling to driven at another value.