CBEA: Competitive balances for taxonomic enrichment analysis
Fig 2
Random taxa set analyses for inference at the sample level of CBEA under different parametric assumptions compared against a Wilcoxon rank-sum test.
Type I error (y-axis) was evaluated by generating random sets of different sizes (x-axis) (500 replications per size) and computing the fraction of samples in which the set was found to be significantly enriched at α = 0.05. Error bars represent the mean type I error ± sample standard error computed across 500 replications of the experiment. Only the unadjusted CBEA with the mixture normal distribution and the Wilcoxon rank sum test were able to control for type I error at 0.05. All approaches are invariant to set sizes.