LncRNAs of Saccharomyces cerevisiae bypass the cell cycle arrest imposed by ethanol stress
Fig 5
Simulating the SEY6210 cell cycle under ethanol stress with in silico overexpression of lnc9136 (the third experimental model simulation in Fig 1).
The box color indicates the node levels in each simulation state. The simulation presented a cyclic attractor related to a functional cell cycle, which includes all states depicted on the X-axis. Thus, the functional cell cycle is evidenced when the simulation outcomes cyclic attractors presenting the activation of all phenomenological nodes, further inhibited when the MITOSIS_EXIT node reaches ’2’, and restarting the cell cycle (MASS returning to ’0’), as observed here (see details in the ’Model cycling rationale’ in the Materials and Methods). The upper picture in the box on the left is the LT cell cycle arrest mechanism reported in Fig 4, while the bottom picture reports our suggested M arrest skip mechanism that may occur in cells under ethanol stress. The red ’X’ depicts suppression of a given regulation. The red ’X’ on the edge head ended at the Swe1 node, indicates that this node was blocked neither by Gin4 nor Hsl1 when lnc9136 was overexpressed under ethanol (EtOH) stress.