Calcium modeling of spine apparatus-containing human dendritic spines demonstrates an “all-or-nothing” communication switch between the spine head and dendrite
Fig 4
Passive spine SA spine-to-dendrite signaling.
Effects of passive spine SA on spine-to-dendrite Ca2+ signaling, with PSD adjusted Ca2+ influx. Plots in row A are without SA and plots in row B are with SA, showing [Ca2+] profiles for 10 ms initial Ca2+ release into the spine head. Consistent with experimental data, spine-to-dendrite Ca2+ signaling does not occur for all 9 simulated spines. Presence of a passive SA, i.e., no ryanodine receptors, has no major effect on Ca2+ dynamics in the spine head and neck.