Calcium modeling of spine apparatus-containing human dendritic spines demonstrates an “all-or-nothing” communication switch between the spine head and dendrite
Fig 2
Morphological parameter of reconstructed spines.
(A) Three-dimensional models based on reconstructed human dendritic spines. Spine apparatus organelle, green. Postsynaptic density, cyan. Scale bar, 200 nm (B) Dendritic spines with large volumes have large postsynaptic densities. (C) Positive correlation between spine neck diameter and postsynaptic density sizes. (D) Postsynaptic densities in large spines are not further away from spine base. (E) Large spines contain large spine apparatus organelles, which are found in spines with wider spine necks. n = 9 reconstructed dendritic spines from 7 independent samples.