Multiscale modeling of presynaptic dynamics from molecular to mesoscale
Fig 8
Convolutional Filter Applied to a Component of a Release Rate Function.
Toy model with P = 5, τ = 10 ms, k = 0.5 ms–1, μ = 5 ms, and σ = 1 ms. (A) Unfiltered release rate component. (B) MCMC ex-Gaussian filter shape. (C) Filtered release profile produced by convolving the release rate profile with the temporal delay filter. (D-F) Release rates in response to spike trains without applying delay filter. (G-I) Release rates in response to spike trains with delay filter applied. (D,G) Response to one spike. (E,H) Response to two spikes. (F,I) Response to multiple spikes. Dotted lines show how the histogram of response to one spike falls off with interference from the response to the following spike. Spike times at 0, 15, 20, 30, and 50 ms.