Multiscale modeling of presynaptic dynamics from molecular to mesoscale
Fig 6
Synchronous and Asynchronous Release Rates in Response to Ca2+ Impulse at Different Resting Concentrations.
Instantaneous impulse of Ca2+ delivered at 10 ms. Solid lines represent true release rate; dotted lines have spontaneous rates subtracted off to show secondary exponential components. Black lines show release rate decaying with a single exponential component with no baseline [Ca2+]i. For other curves, [Ca2+]i0 ranges from 0.001 μM to 10 μM. (A) Synchronous release rate over time: S(t). (B) Asynchronous release rate over time: A(t). (C) Instantaneous release rate decay time constants for synchronous and asynchronous mechanisms. Fast components (lower blue and red lines) determined from profiles with [Ca2+]i0 = 0 (black lines in A and B). Slower components (upper blue and red curves) determined from cases with small [Ca2+]i0.