Multiscale modeling of presynaptic dynamics from molecular to mesoscale
Fig 4
Synchronous and Asynchronous Release in MCell.
Color indicates distance from VDCC source, with yellow representing a nearby Ca2+ sensor and dark blue a distant one (as in Fig 2A and 2B). Action-potential-like stimulus delivered at 0 ms (left), followed by another at 20 ms (center) and 100 ms (right). (A) Spike-evoked Ca2+ traces that drive release. (B) Synchronous release raster. (C) Asynchronous release raster. (D) Synchronous (tall, thin bars) and asynchronous (short, wide bars) release stacked histogram. Most synchronous releases happen close to the Ca2+ source; asynchronous releases distributed across all distances.