Towards reliable quantification of cell state velocities
Fig 6
Eco-velo as an alternative to computationally costly reaction rate parameter recovery.
A. Under certain conditions, a cell’s unspliced state will represent the cell’s future spliced state. To infer velocities, we look for the first MNN between a cell’s unspliced counts and other cells’ spliced counts. We draw an arrow from the cell to the identified MNN. B. We validate eco-velo on simulation and visualise the resulting velocities on t-SNE. C. eco-velo on pancreas endocrinogenesis.