Survival analysis of pathway activity as a prognostic determinant in breast cancer
Fig 2
Heatmap of the coefficients of the Pearson correlation matrix between the variables survival time, the eigengene of the gene expression values, and the gene expression values within the pathway ‘Metabolism of folate and pterines” for samples from diseased patients.
We sorted the genes in the expression matrix by their contribution to the eigensample and encompassed them with a dotted line. The patients’ survival time both correlates and anti-correlates with the different genes. However, the eigengene captures the covariational trend within the expression data and correlates well with the patients’ survival time.