Dissecting mutational allosteric effects in alkaline phosphatases associated with different Hypophosphatasia phenotypes: An integrative computational investigation
Fig 5
Network topological and dynamic analysis of mutations in ALPL.
(A)ΔDC, (B) ΔBC, (C) ΔCC, (D) ΔC, (E) MSF, (F) effectiveness, (G) sensitivity, (H) MBS, and (I) stiffness profiles for the three types of mutations. Control, mild and severe mutations are represented as blue, orange, and red bars, respectively.