Dissecting mutational allosteric effects in alkaline phosphatases associated with different Hypophosphatasia phenotypes: An integrative computational investigation
Fig 4
(A) The folding free energy changes induced by single point mutations. The profiles of mild, severe, and control mutations are shown as yellow, red and blue bars, respectively. (B) The significant difference between the predicted folding free energy change of ALPL single residue variations in the control, mild, severe groups was measured by Wilcoxon. test, with P values<0.01. (C) The structural distribution of disease-causing mutations with low ΔΔG.