Dissecting mutational allosteric effects in alkaline phosphatases associated with different Hypophosphatasia phenotypes: An integrative computational investigation
Fig 3
The (A) entropy (S(i)), (B) coevolutionary (MI) and (C) relative solvent accessible area (RASA) profiles for each residue in TNSALP; mild, severe, and control mutations are highlighted as yellow, red, and blue diamonds, respectively. The comparison of (D) the S(i), (E) MI and (F) RASA, between the control group mutations and mild and severe mutations. Statistical significance was determined by the Wilcoxon signed-ranked test, with P values<0.01.