Optimizing clinical dosing of combination broadly neutralizing antibodies for HIV prevention
Fig 2
Correlations among PKPD outcomes and between model parameters and outcomes.
A) Many metrics for PKPD outcomes are highly correlated (yellow in heatmap) and cluster into approximately 6 distinct categories: see labels. The minimum interaction was distinct across all outcomes. B) Of the 10 varied model parameters (Table 2), half-lives and resistant fractions had the largest impact on representative members of each of 6 categories from A. All categories were similarly sensitive to half-lives, whereas titer and minimum categories were less sensitive to resistance fractions. The ratio does not strongly predict any outcomes relative to variation in all other parameters, a sign that there is no general solution to optimizing the ratio and it must be adjusted on a case-by-case basis.