Validation-based model selection for 13C metabolic flux analysis with uncertain measurement errors
Fig 13
Validation of lipid synthesis in HMEC cultures.
(A) Schematic of the model for lysophosphatidylcholine (LPC) 16:0 synthesis from acetate (ac). (B) Predicted MID of ac from the model selected by the “Validation” method. (C) Measured MID of glycerol-3-phosphocholine (g3pc). (D) Fitted (gray) and measured (black) MID of LPC 16:0. Mean values of biological triplicates are shown in (C, D). Error bars indicate standard deviation.