Validation-based model selection for 13C metabolic flux analysis with uncertain measurement errors
Fig 11
Usage of prediction uncertainty to demonstrate that the validation data has neither too little, nor too much, novelty, compared to the estimation data.
This analysis shows the result from the simulated 13C MFA example (Fig 7–9). The model was trained on estimation data corresponding to three tracers: Tracer 1 = 1,2-13C-glutamine (dark red), Tracer 2 = 3-13C-pyruvate (red), and Tracer 3 = U-13C-glutamine (light red). The validation data (dark blue) came from usage of tracer U-13C-pyruvate. For the experimental data, the error bars represent standard deviation, and for the model predictions (light blue), the error bars represent model uncertainty (Section 4.4).