< Back to Article

Multi-targeting of K-Ras domains and mutations by peptide and small molecule inhibitors

Fig 4

Interaction mode of peptides/molecule with K-Ras^G12D and K-Ras^G13D.

Superimposition of top-ranked peptide-protein docked poses resulted from flexible docking of (A) the modified Retro-Kras^G12D, (B) the modified LfcinB- Kras^G12D, (C) the modified Retro-Kras^G13D, and (D) the modified LfcinB-Kras^G13D. (E) Superimposition of GNP-bound (green) and Zinc12502230-bound (blue) K-Ras^G12D. (F) Close-up view of H-bonding interactions between Zinc12502230 (blue) and five residues of K-Ras^G12D colored in different colors.

doi: https://doi.org/10.1371/journal.pcbi.1009962.g004