Addressing the mean-correlation relationship in co-expression analysis
Fig 10
Mean-correlation relationship in scRNA-seq data.
scRNA-seq data from [16] containing 60 cells, with either 4 PCs removed (a-b) or 16 PCs removed (c-d). The later value is the result of using SVA to estimate the number of PCs as suggested by [11]. (a) Like Fig 3a, i.e. densities of the Pearson correlation between all genes within each of 10 expression bins (background, blue) as well as the top 0.1% correlations (possible signal, red). (b) Like Fig 5d, i.e. the expression level of pairs of genes in different subsets (all genes (black), genes above the 0.1% threshold with (orange) and without SpQN (gray)). (c) Like (a) but for data with 16 PCs removed. (d) Like (b) but for data with 16 PCs removed.