Addressing the mean-correlation relationship in co-expression analysis
Fig 6
IQR of gene-gene correlation distributions in each bin for 9 tissues.
RNA-seq data from [15] from 9 tissues with 4 PCs removed. A point in this figure corresponds to one submatrix in a given gene-gene correlation matrix for each tissue, before and after SpQN. (a) Background IQR for unadjusted (left smear) and SpQN-adjusted (right smear) gene-gene correlation distributions for all expression bins across 9 GTEx tissues. Color indicates expression level. (b) The relationship between sample size for a tissue and background IQR for correlation distributions before and after SpQN adjustment.