Addressing the mean-correlation relationship in co-expression analysis
Fig 3
The mean-correlation relationship leads to expression bias.
Same data as Fig 2. (a) Like Fig 2a, but supplemented with the densities (scaled differently from the background densities) of the top 0.1% of the correlations in each expression bin, representing possible signal. (b) We calculate the average expression level between two genes involved in a gene-gene correlation, as a measure of the expression level of the pair. The expression level of pairs of genes for either all expressed genes (black) or all gene pairs in the top 0.1% of the correlations (gray). (c) The expression level of pairs of genes for either all genes (black) or all gene pairs with a known protein-protein interaction (PPI) (pink).(d) The expression level of pairs of genes for either all genes (black) or all gene pairs within a regulatory pathway (green).