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Covalent docking and molecular dynamics simulations reveal the specificity-shifting mutations Ala237Arg and Ala237Lys in TEM beta-lactamase

Fig 8

Analysis of the number of interactions between ampicillin or cefixime and Arg237 of TEM-Ala237Arg complexes.

Data are averaged from ten replicates of MD simulations. The shading denotes the standard deviation of the number of interactions for each system.

doi: https://doi.org/10.1371/journal.pcbi.1009944.g008