Integrative experimental/computational approach establishes active cellular protrusion as the primary driving force of phagocytic spreading by immune cells
Fig 7
Predictions of the protrusive zipper model with discrete adhesion sites.
(A) Two time series (times shown at the left) of simulation snapshots illustrate how the progression of the model cell’s leading edge is affected by the spacing of discrete adhesion sites. Unoccupied binding sites are depicted by empty circles, whereas filled circles indicate that the cell membrane is locally attached. (B) Contact-area-versus-time curves share similar slopes over three orders of magnitude of ligand density, but plateau at different maximum contact areas.