The impact of the spatial heterogeneity of resistant cells and fibroblasts on treatment response
Fig 14
Complex dynamics of multiple metastases under AT and CT-MTD.
The time evolution of the total cell population in the four metastases is shown in the sub-figures for Case I. The first and second columns show the results for the initial clumped and random cell configurations in the invisible metastasis, respectively. In each sub-figure, the blue, red, yellow, and black colors show the total cell populations in metastasis 1, metastasis 2, metastasis 3, and metastasis 4, respectively; the vertical cyan lines show the emergence time (ET) of the invisible metastasis, and the red line shows the TTP. The solid and dashed lines show results under CT-MTD and AT, respectively.