The impact of the spatial heterogeneity of resistant cells and fibroblasts on treatment response

doi:10.1371/journal.pcbi.1009919

The impact of the spatial heterogeneity of resistant cells and fibroblasts on treatment response

Fig 10

CAF-mediated growth with clumped initial R-cell distribution and cell migration (α = 2, m = 1).

(A) The time evolution of the average of the total cell population () under CT-MTD in the 30 simulations is shown for all types of CAF configurations. (B) Boxplot of the time to progression (TTP) under CT-MTD in the 30 realizations. (C) Boxplot of the time to progression under AT in the 30 realizations. (D) Correlation of TTP with the perimeter of impact. The circles and the asterisks (the colors are similar to the legend in A) show the TTP under CT-MTD and AT respectively. solid line: CT-MTD and dashed line: AT regression line. The p − values for AT and CT-MTD indicate significance of the correlation. (E) Time gain (TG) is shown as boxplots for all type of CAF distributions.

doi: https://doi.org/10.1371/journal.pcbi.1009919.g010