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The impact of the spatial heterogeneity of resistant cells and fibroblasts on treatment response

Fig 9

Consequences of CAF-mediated resistance with clumped initial R-cell distribution.

(A) The time evolution of the average of the total cell population () in the 30 simulations is shown for CT-MTD for all types of fibroblast configurations. NoF: no fibroblast, FC: fibroblast overlapping with the R-cell clump at the center of domain, FCp: fibroblast partially overlapping with the R-cell clump at the center, FSq: fibroblast completely surrounding the R-cell clump. FSp: fibroblast over a “L” shaped region, partially surrounding the R-cell clump, FR: fibroblast clumps randomly placed in the domain. (B) Boxplot of the time to progression (TTP) in the 30 realizations under CT-MTD. (C) Boxplot of the time to progression (TTP) in the 30 realizations under AT is shown. (D) Correlation of TTP with the area of impact is shown. The circles and the asterisks (the colors are similar to the legend in A) show the TTP under CT-MTD and AT respectively. The solid and dashed lines are the respective regression lines (sold line: CT-MTD, dashed line: AT). The p − values for AT and CT-MTD indicate significance of the correlation. (E) Time gain (TG) is shown as boxplots for all six types of fibroblast distributions.

doi: https://doi.org/10.1371/journal.pcbi.1009919.g009