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The impact of the spatial heterogeneity of resistant cells and fibroblasts on treatment response

Fig 7

Effects of cell migration on treatment responses.

(A) The time evolution of the mean of the total cell population () in the 30 simulations is shown for m = 0 (blue), 2r_S (red), and 4r_S (yellow) under AT (dashed line) and CT-MTD (solid line) with N(0) = 5000, f₀ = 10%. The vertical solid lines show the time to tumor progression (TTP) under CT-MTD. The vertical dashed line shows the TTP under AT. The horizontal cyan line shows the 120% level of the initial cell population (progression threshold). (B) The same result as in A is shown for N(0) = 7000, f₀ = 1%. (C) The time evolution of the mean of the average number of empty sites in the VNHD of each R-cell in the 30 realizations () is shown with the same line styles as in A. (D) The same result as in C is shown for N(0) = 7000, f₀ = 1%. (E) The boxplots of the TG for m = 0, r_S, 2r_S, 3r_S, 4r_S are shown. (F) The same result as in D is shown for N(0) = 7000, f₀ = 1%.

doi: https://doi.org/10.1371/journal.pcbi.1009919.g007