The impact of the spatial heterogeneity of resistant cells and fibroblasts on treatment response
Fig 6
Role of the initial R-cell distribution on the benefit of AT over CT-MTD.
(A) The blue and red bars show the TTP for N(0) = 5000 and 7000 respectively under both treatment strategies and different initial R-cell configurations of c (clumped), r(random) and u(uniform) for f0 = 10%. (B) Similar results to those in A are shown for f0 = 1%. (C) The boxplots show the TG in the 30 realizations for the clumped, random, and uniform initial cell configurations for f0 = 10% (***: p − value < 0.001; n.s.: not significant). The blue shaded and orange shaded regions show results for N(0) = 5000 and 7000 respectively. (D) Similar results to those in C are shown for f0 = 1%.