The impact of the spatial heterogeneity of resistant cells and fibroblasts on treatment response
Fig 4
Effects of initial R-cell distribution on the TTP under CT-MTD.
(A) The cell configurations on days 1, 120, and 2000 are shown. The blue, orange, and white dots are S-cells, R-cells, and empty sites, respectively. (B) The average temporal evolution of the average number of S-cell and R-cell populations over 30 realizations with clumped (upper panel), random (middle panel), and uniform (bottom panel) initial cell configurations (blue: S-cell, orange: R-cell). Black solid line: average total cell population (). Vertical cyan line: TTP in each case; horizontal cyan line: the 120% level of the initial tumor volume (tumor progression threshold). The average numbers of empty sites (
) and R-cells (
) in the VNHD of an R-cell in the 30 realizations are shown as boxplots in (C) and (D), respectively, for i = c, r, u. The blue, orange, and yellow boxes are for the clumped (c), random (r), and uniform (u) cases, respectively.