Causal reasoning over knowledge graphs leveraging drug-perturbed and disease-specific transcriptomic signatures for drug discovery
Table 2
Top 5 prioritized protein target-disease pairs.
These results were obtained by running RPath over both KGs with the GEO and Open Targets datasets using the same path length as the drug discovery task (see Methods). Pairs were prioritized based on the number of concordant paths. The vast majority of pairs were prioritized using the disease transcriptomic signatures from the GEO dataset given its larger coverage of measured genes compared to Open Targets (S4 Table).