Causal reasoning over knowledge graphs leveraging drug-perturbed and disease-specific transcriptomic signatures for drug discovery
Fig 2
Devoncoluting the mechanism of action of a drug through RPath.
By investigating all the paths of a given length between a drug and a disease in a KG, we can analyze the different mechanisms that are proposed by RPath. a) Visualization of the custom KG. Proteins are colored in blue, diseases in red and drugs in green. Sankey diagram illustrating a sample of the paths between ponatinib and AML (b) and bicalutamide and prostate cancer (c) for the custom KG. Activatory relations in the Sankey diagrams are colored in red and inhibitory relations in blue.