Mapping the gene network landscape of Alzheimer’s disease through integrating genomics and transcriptomics
Fig 5
Cell-specific gene expression across clusters and schematic model.
A) Mean expression (FPKM) from brain cell-types averaged across genes in each cluster (functional annotations for identified clusters are 1: Immunoregulatory interactions between a lymphoid and non-lymphoid cell, 2: RNA metabolic process, 3: Complement activation, 4: Protein modification by small protein conjugation, 5: Clathrin-mediated endocytosis, 6: SNARE binding, 7: Regulation of plasma lipoprotein particle levels, 8: EPH-Ephrin signaling, 9: DNA-binding transcription factor activity, 10: Acetylcholine-gated cation-selected channel activity, 11: Interleukin-1 signaling, 12: GABAergic synapse). B) Classes of identified pathways that are functionally related are presented as inner circles, with circle size roughly indicating relative class sizes. The overlying outer circle illustrates the types of cells in the central nervous system with overall preferential gene expression in each major class (e.g., microglia overlay the classes of Immune reactions and Substance metabolism because genes in multiple clusters of these two classes were highly expressed in microglia).