Mapping the gene network landscape of Alzheimer’s disease through integrating genomics and transcriptomics
Fig 2
Expanded AD disease module and highlighted distinctive clusters annotating different biological pathways possibly involved in AD.
Clusters identified in the expanded AD module labeled in the center. Genes comprising 5 selected clusters are depicted around the edges of the figure. The temporal cortex RNAseq beta statistic is mapped to the gene color, and shape indicates AD GWAS seed gene (triangle) or network proximal gene (z > 2, circle). Bold black outlines indicate AGORA proposed drug targets (e.g. CHRNA2, PTK2B). Seed genes or genes with AGORA targets are labeled with a larger font, while other genes identified by network propagation are labeled with a smaller font.