Mapping the gene network landscape of Alzheimer’s disease through integrating genomics and transcriptomics
Fig 1
142 GWAS-identified AD genes were included as the seed genes of the AD disease module, and propagated to an expanded network consisting of another 646 predicted proximal genes based on the background protein-protein interactome (STRING). The expanded AD module was used for further functional annotation, pathway clustering and gene expression analyses integrating with transcriptomic data.