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Phylogenetic analysis of migration, differentiation, and class switching in B cells

Fig 5

Analysis of B cell subtypes in three HIV+ subjects.

(a) Example tree visualized using ggtree [38,39] showing observed relationship between CD19^hi MBCs and GCBCs. (b-d) Direction of significant SP test δ values for subjects 1 (b), 2 (c), and 3 (d). Arrows within each diagram show the direction of significantly high (blue) or significantly low (red) SP statistics between CD19^hi MBCs, CD19^lo MBCs, unswitched MBCs (Unsw), and GCBCs in each subject.

doi: https://doi.org/10.1371/journal.pcbi.1009885.g005