A three-dimensional multiscale model for the prediction of thrombus growth under flow with single-platelet resolution
Fig 7
Simulation results of platelet aggregation under pathological shear rates in a stenosis at the time of vessel occlusion.
Schematic of the stenotic geometry: (A) oblique view and (D) side view. Inlet and outlet of the stenosis maintained at a constant pressure drop across the length of the geometry that corresponded to an initial inlet wall shear rate of 1000s-1. Surface collagen: red bar. (B,E) Platelet activation (blue indicates inactivated and red, highly activated) and deposition at occlusion time. (C) Dynamics of platelet aggregate density observed over time. Released (F) ADP and (G) TXA2 contours plotted along the along the center of the tube at the time of occlusion.