A three-dimensional multiscale model for the prediction of thrombus growth under flow with single-platelet resolution
Fig 3
Comparison between prior 2D simulations and present 3D simulations.
(A) Thrombus morphology observed in 2D simulations (top) showing highly dendritic aggregate growth. A clot remodeling scheme was required in 2D to obtain a realistic morphology (middle). Thrombus morphology observed in 3D without employing a remodeling scheme (bottom). (B) Thrombus morphology observed in present work in 3D. Dendritic aggregate formation is drastically reduced due to realistic platelet trajectories in 3D, as evidenced by flow streamlines (black lines) that show flow around aggregates.