A three-dimensional multiscale model for the prediction of thrombus growth under flow with single-platelet resolution
Fig 2
Simulation results of platelet aggregation under flow in the microfluidic device.
Schematic of the microfluidic device geometry: (A) oblique view and (D) side view. Inlet flow: 200s-1; reactive surface containing collagen and TF: red bar. (B,E) Platelet activation (blue indicates inactivated and red, fully activated) and deposition after 400 seconds. (C) Dynamics of platelet aggregate count observed over time. Released (F) ADP and (G) TXA2, and (H) the local shear rate contours plotted along the center of the channel after 400 seconds.