Regulatory network-based imputation of dropouts in single-cell RNA sequencing data
Fig 3
Comparison of impact of different imputation methods on cell trajectory inference for time course hESC differentiation data.
Cells were projected onto the trajectories determined with slingshot to compute a pseudotime of differentiation. The pseudotime assigned to each individual cell (y-axis) is then compared to the time point label of the sample (x-axis). Colored points represent the mean pseudotime per known time point. In the title, the Pearson’s r between pseudotime and time point labels (and the respective p-value) are shown. Note that slingshot always fails to correctly position the sample at time point 0, suggesting an artifact in the original data.