Autocrine signaling can explain the emergence of Allee effects in cancer cell populations
Fig 1
Overview of the mechanisms assumed in the model.
Cancer cells divide at a rate α(1 + g), where g is the local growth factor (GF) concentration, and die at a constant rate μ. The GF is produced at rate ρ by all cancer cells and decays at rate δ. Lastly, cells migrate at rate ν. Parameter values are provided in Table 1.