Inference of trajectory presence by tree dimension and subset specificity by subtree cover
Fig 9
Distinct cellular and pathway trajectories in single-cell data of embryonic stem cells.
Cells are clustered into five groups indicated by the colors. (A) Observed gene expression data of embryonic stem cells in the first three principal components. (B) The EMST of the entire transcriptome suggests a strong trajectory pattern at the cellular level. (C)-(F) EMST representations of trajectory patterns in embryonic stem cells using gene expression on the pathways of (C) renin, (D) proteasome, (E) mismatch repair, and (F) hedgehog.