Inference of trajectory presence by tree dimension and subset specificity by subtree cover
Fig 6
Trajectory presence testing on 229 simulated single-cell datasets.
(A) ROC curves and AUROC scores for TDT effect size S/N, number of leaves L and tree diameter Dm. (B) PR curves and AUPR scores for the three methods. (C) The PCA plot of a multifurcating trajectory patterns, points represent cell and the axes gene expression, and the EMST representation of trajectory pattern, with each point representing a cell. Text shows p-values of each method when applied on the dataset. (D) PCA and EMST plots of a looping trajectory pattern. (E) PCA and EMST plots of a multifurcating trajectory. (F)–(H) PCA and EMST plots of datasets with no significant trajectory patterns.