Analytical kinetic model of native tandem promoters in E. coli
Fig 3
Events leading to transcriptional interference between tandem promoters.
(A) Sequence of events in transcription in isolated promoters. A similar set of events occurs in tandem promoters, if only one RNAP interacts with them at any given time. (B / C) Interference due to the occlusion of the downstream / upstream promoter by a bound RNAP, which will impede the incoming RNAP from binding to the TSS. (D) Interference of the activity of the RNAP incoming from the upstream promoter by the RNAP occupying the downstream promoter. One of these RNAPs will be dislodged by the collision. Created with BioRender.com.